Drug interactions
Meclofenamate + Mefenamic acid
Severity: Major
Meclofenamate and Mefenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are fenamate NSAIDs, so combining them provides no added benefit and increases the risk of GI bleeding, renal injury, fluid retention and hyperkalemia. This is therapeutic duplication.
What this interaction means in plain words
Meclofenamate and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate COX inhibition leading to additive adverse effects on gastric mucosa, platelets and renal prostaglandin-dependent function.
What to do
Avoid using two NSAIDs together; choose one agent at the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Meclofenamate with Mefenamic acid?
MediHelp rates the interaction as major. Meclofenamate and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are fenamate NSAIDs, so combining them provides no added benefit and increases the risk of GI bleeding, renal injury, fluid retention and hyperkalemia. This is therapeutic duplication.
How serious is the interaction between Meclofenamate and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAIDs together; choose one agent at the lowest effective dose.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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