Drug interactions
Meclofenamate + Metoprolol
Severity: Moderate
Meclofenamate and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the blood pressure-lowering effect of beta-blockers, especially with continued use over more than a week. Blood pressure control may deteriorate, and renal function can be affected in susceptible patients.
What this interaction means in plain words
Meclofenamate and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and fluid retention and counteracts the antihypertensive effect.
What to do
Monitor blood pressure when an NSAID is used regularly with metoprolol. Use the lowest effective NSAID dose for the shortest time, or consider an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Meclofenamate with Metoprolol?
MediHelp rates the interaction as moderate. Meclofenamate and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the blood pressure-lowering effect of beta-blockers, especially with continued use over more than a week. Blood pressure control may deteriorate, and renal function can be affected in susceptible patients.
How serious is the interaction between Meclofenamate and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is used regularly with metoprolol. Use the lowest effective NSAID dose for the shortest time, or consider an alternative analgesic such as paracetamol.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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