Drug interactions
Meclofenamate + Moxifloxacin
Severity: Moderate
Meclofenamate and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and convulsions. The risk is greater in patients with epilepsy, prior seizures, or renal impairment.
What this interaction means in plain words
Meclofenamate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, possibly enhanced by NSAIDs; the exact mechanism is not fully established.
What to do
Monitor for neurologic symptoms such as tremor, agitation or seizures, and avoid the combination in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Meclofenamate with Moxifloxacin?
MediHelp rates the interaction as moderate. Meclofenamate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase the risk of CNS stimulation and convulsions. The risk is greater in patients with epilepsy, prior seizures, or renal impairment.
How serious is the interaction between Meclofenamate and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic symptoms such as tremor, agitation or seizures, and avoid the combination in patients with a seizure history.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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