Drug interactions
Meclofenamate + Mycophenolate mofetil
Severity: Minor
Meclofenamate and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate and mycophenolic acid glucuronide are both acidic and may compete for renal tubular secretion. This could modestly raise metabolite levels. Clinical significance is uncertain, and NSAIDs also add renal and GI risk.
What this interaction means in plain words
Meclofenamate and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide by an acidic NSAID.
What to do
Monitor blood counts and renal function, and use the lowest effective NSAID dose for the shortest time. Consider an alternative analgesic in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Meclofenamate with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Meclofenamate and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclofenamate and mycophenolic acid glucuronide are both acidic and may compete for renal tubular secretion. This could modestly raise metabolite levels. Clinical significance is uncertain, and NSAIDs also add renal and GI risk.
How serious is the interaction between Meclofenamate and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, and use the lowest effective NSAID dose for the shortest time. Consider an alternative analgesic in renal impairment.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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