Drug interactions
Meclofenamate + Piroxicam
Severity: Major
Meclofenamate and Piroxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two systemic NSAIDs adds gastrointestinal, renal and bleeding risks without improving efficacy. Hyperkalemia and renal impairment may also be more likely.
What this interaction means in plain words
Meclofenamate and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate cyclooxygenase inhibition causes additive effects on gastric mucosa, platelets and renal prostaglandin synthesis.
What to do
Avoid concurrent use of two NSAIDs and keep only one agent. If a switch is needed, stop the first drug before starting the second.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Meclofenamate with Piroxicam?
MediHelp rates the interaction as major. Meclofenamate and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two systemic NSAIDs adds gastrointestinal, renal and bleeding risks without improving efficacy. Hyperkalemia and renal impairment may also be more likely.
How serious is the interaction between Meclofenamate and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and keep only one agent. If a switch is needed, stop the first drug before starting the second.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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