Drug interactions
Meclofenamate + Rivaroxaban
Severity: Moderate
Meclofenamate and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that impairs platelet function and can injure the gastric mucosa. Combined with rivaroxaban, the risk of bleeding, especially gastrointestinal, is higher.
What this interaction means in plain words
Meclofenamate and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: NSAID platelet inhibition and mucosal injury combined with factor Xa inhibition.
What to do
Avoid the NSAID where possible and use the lowest effective dose for the shortest time if needed. Monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Meclofenamate with Rivaroxaban?
MediHelp rates the interaction as moderate. Meclofenamate and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that impairs platelet function and can injure the gastric mucosa. Combined with rivaroxaban, the risk of bleeding, especially gastrointestinal, is higher.
How serious is the interaction between Meclofenamate and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID where possible and use the lowest effective dose for the shortest time if needed. Monitor for bleeding and consider gastroprotection.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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