Drug interactions
Meclofenamate + Tacrolimus
Severity: Major
Meclofenamate and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis and, with tacrolimus, can increase the risk of acute kidney injury and hyperkalemia. The effect is greatest in volume depletion or existing renal impairment.
What this interaction means in plain words
Meclofenamate and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive renal vasoconstriction from NSAID prostaglandin inhibition and tacrolimus afferent arteriolar constriction.
What to do
Avoid NSAIDs in tacrolimus-treated patients and use paracetamol or another alternative for analgesia. If unavoidable, use the shortest course and monitor creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Meclofenamate with Tacrolimus?
MediHelp rates the interaction as major. Meclofenamate and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin synthesis and, with tacrolimus, can increase the risk of acute kidney injury and hyperkalemia. The effect is greatest in volume depletion or existing renal impairment.
How serious is the interaction between Meclofenamate and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs in tacrolimus-treated patients and use paracetamol or another alternative for analgesia. If unavoidable, use the shortest course and monitor creatinine and potassium.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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