Drug interactions
Meclofenamate + Torsemide
Severity: Moderate
Meclofenamate and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the diuretic and blood pressure lowering effects of torsemide. The combination also increases the risk of acute kidney injury, especially with dehydration.
What this interaction means in plain words
Meclofenamate and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal blood flow and sodium excretion.
What to do
Monitor weight, edema, blood pressure and renal function. Use the lowest NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Frequently asked questions
Can I take Meclofenamate with Torsemide?
MediHelp rates the interaction as moderate. Meclofenamate and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce the diuretic and blood pressure lowering effects of torsemide. The combination also increases the risk of acute kidney injury, especially with dehydration.
How serious is the interaction between Meclofenamate and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function. Use the lowest NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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