Drug interactions
Meclofenamic acid + Mesalamine
Severity: Moderate
Meclofenamic acid and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause kidney injury, so combined use may raise the risk of nephrotoxicity, especially in patients with existing renal disease or dehydration.
What this interaction means in plain words
Meclofenamic acid and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
NSAID-induced reduction of renal perfusion adds to the interstitial nephritis potential of mesalamine.
What to do
Monitor serum creatinine at baseline and periodically during combined use, and stop the NSAID if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Mesalamine
Frequently asked questions
Can I take Meclofenamic acid with Mesalamine?
MediHelp rates the interaction as moderate. Meclofenamic acid and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause kidney injury, so combined use may raise the risk of nephrotoxicity, especially in patients with existing renal disease or dehydration.
How serious is the interaction between Meclofenamic acid and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine at baseline and periodically during combined use, and stop the NSAID if renal function declines.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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