Drug interactions
Meclofenamic acid + Milnacipran
Severity: Moderate
Meclofenamic acid and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with an SNRI such as milnacipran increases the risk of bleeding, especially from the upper gastrointestinal tract.
What this interaction means in plain words
Meclofenamic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
SNRIs deplete platelet serotonin and impair aggregation, while NSAIDs inhibit platelet thromboxane and damage gastric mucosa, giving additive bleeding risk.
What to do
Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in patients at higher risk. Avoid prolonged combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Milnacipran?
MediHelp rates the interaction as moderate. Meclofenamic acid and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with an SNRI such as milnacipran increases the risk of bleeding, especially from the upper gastrointestinal tract.
How serious is the interaction between Meclofenamic acid and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in patients at higher risk. Avoid prolonged combined use where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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