Drug interactions
Meclofenamic acid + Pemetrexed
Severity: Major
Meclofenamic acid and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce pemetrexed renal clearance, particularly in patients with mild to moderate renal impairment, raising the risk of myelosuppression, renal and gastrointestinal toxicity.
What this interaction means in plain words
Meclofenamic acid and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Why it happens
NSAID-related reduction in renal perfusion and tubular secretion decreases pemetrexed elimination.
What to do
In patients with creatinine clearance of 45 to 79 mL/min, withhold short half-life NSAIDs for 2 days before, the day of and 2 days after pemetrexed. Monitor blood counts and renal function if an NSAID cannot be stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Pemetrexed
Frequently asked questions
Can I take Meclofenamic acid with Pemetrexed?
MediHelp rates the interaction as major. Meclofenamic acid and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce pemetrexed renal clearance, particularly in patients with mild to moderate renal impairment, raising the risk of myelosuppression, renal and gastrointestinal toxicity.
How serious is the interaction between Meclofenamic acid and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with creatinine clearance of 45 to 79 mL/min, withhold short half-life NSAIDs for 2 days before, the day of and 2 days after pemetrexed. Monitor blood counts and renal function if an NSAID cannot be stopped.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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