Drug interactions
Meclofenamic acid + Probenecid
Severity: Moderate
Meclofenamic acid and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can raise NSAID concentrations, and NSAIDs may compete with probenecid at the tubule and reduce uricosuric effect. The clinical effect is mostly increased NSAID exposure and adverse effects.
What this interaction means in plain words
Meclofenamic acid and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule, reducing NSAID secretion and increasing its plasma levels.
What to do
Monitor for NSAID adverse effects such as GI upset and renal impairment, and consider reducing the NSAID dose. Watch for loss of uricosuric effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Meclofenamic acid with Probenecid?
MediHelp rates the interaction as moderate. Meclofenamic acid and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can raise NSAID concentrations, and NSAIDs may compete with probenecid at the tubule and reduce uricosuric effect. The clinical effect is mostly increased NSAID exposure and adverse effects.
How serious is the interaction between Meclofenamic acid and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI upset and renal impairment, and consider reducing the NSAID dose. Watch for loss of uricosuric effect.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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