Drug interactions
Meclofenamic acid + Tolazamide
Severity: Moderate
Meclofenamic acid and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is variable and usually mild.
What this interaction means in plain words
Meclofenamic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from albumin binding and reduced clearance; not fully established.
What to do
Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Meclofenamic acid with Tolazamide?
MediHelp rates the interaction as moderate. Meclofenamic acid and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is variable and usually mild.
How serious is the interaction between Meclofenamic acid and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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