Drug interactions
Meclofenamic acid + Vancomycin
Severity: Moderate
Meclofenamic acid and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of vancomycin, which has been described mainly in neonates. Because both are potentially nephrotoxic, the combination may raise vancomycin levels and kidney injury risk.
What this interaction means in plain words
Meclofenamic acid and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces glomerular filtration and vancomycin clearance.
What to do
Monitor vancomycin levels and serum creatinine, and adjust the dose as needed. Avoid NSAIDs in neonates and in patients with renal impairment on vancomycin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Meclofenamic acid with Vancomycin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of vancomycin, which has been described mainly in neonates. Because both are potentially nephrotoxic, the combination may raise vancomycin levels and kidney injury risk.
How serious is the interaction between Meclofenamic acid and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vancomycin levels and serum creatinine, and adjust the dose as needed. Avoid NSAIDs in neonates and in patients with renal impairment on vancomycin.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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