Drug interactions
Meclofenamic acid + Warfarin
Severity: Major
Meclofenamic acid and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs impair platelet function and damage the gastroduodenal mucosa, and meclofenamic acid may also displace warfarin from protein binding. The risk of serious bleeding is substantially increased.
What this interaction means in plain words
Meclofenamic acid and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.
Why it happens
Pharmacodynamic synergism through platelet inhibition and mucosal injury, with possible protein-binding displacement of warfarin.
What to do
Avoid concurrent use and use paracetamol or other non-NSAID options. If unavoidable, monitor INR closely, add gastroprotection and watch for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Meclofenamic acid with Warfarin?
MediHelp rates the interaction as major. Meclofenamic acid and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs impair platelet function and damage the gastroduodenal mucosa, and meclofenamic acid may also displace warfarin from protein binding. The risk of serious bleeding is substantially increased.
How serious is the interaction between Meclofenamic acid and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use paracetamol or other non-NSAID options. If unavoidable, monitor INR closely, add gastroprotection and watch for bleeding.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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