Drug interactions
Mefenamic acid + Nefazodone
Severity: Moderate
Mefenamic acid and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants that block serotonin reuptake impair platelet aggregation, and combined with NSAIDs they increase the risk of gastrointestinal bleeding. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is likely lower but still plausible.
What this interaction means in plain words
Mefenamic acid and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from reduced platelet serotonin uptake and NSAID COX-1 inhibition, plus NSAID mucosal injury.
What to do
Monitor for GI bleeding signs and consider gastroprotection in older or high-risk patients; use the shortest NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Nefazodone?
MediHelp rates the interaction as moderate. Mefenamic acid and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antidepressants that block serotonin reuptake impair platelet aggregation, and combined with NSAIDs they increase the risk of gastrointestinal bleeding. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is likely lower but still plausible.
How serious is the interaction between Mefenamic acid and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and consider gastroprotection in older or high-risk patients; use the shortest NSAID course.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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