Drug interactions
Mefenamic acid + Noni juice
Severity: Minor
Mefenamic acid and Noni juice: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content, and NSAIDs can reduce renal potassium excretion by suppressing renin and aldosterone. Hyperkalemia could occur, mainly in patients with kidney disease or taking other potassium-raising drugs.
What this interaction means in plain words
Mefenamic acid and Noni juice have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potassium load from noni juice with NSAID-induced reduction in renal potassium excretion.
What to do
Avoid regular noni juice in patients with renal impairment or on ACE inhibitors, ARBs or potassium-sparing diuretics; check serum potassium if combined.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Noni juice?
MediHelp rates the interaction as minor. Mefenamic acid and Noni juice have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Noni juice has a high potassium content, and NSAIDs can reduce renal potassium excretion by suppressing renin and aldosterone. Hyperkalemia could occur, mainly in patients with kidney disease or taking other potassium-raising drugs.
How serious is the interaction between Mefenamic acid and Noni juice?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular noni juice in patients with renal impairment or on ACE inhibitors, ARBs or potassium-sparing diuretics; check serum potassium if combined.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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