Drug interactions
Mefenamic acid + Pau d'arco
Severity: Minor
Mefenamic acid and Pau d'arco: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pau d'arco contains naphthoquinones with possible anticoagulant activity, giving a theoretical bleeding risk with NSAIDs. No documented clinical cases confirm this.
What this interaction means in plain words
Mefenamic acid and Pau d'arco have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on hemostasis (theoretical); not established.
What to do
Counsel the patient to report bleeding or bruising and avoid the combination in those at high bleeding risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Pau d'arco?
MediHelp rates the interaction as minor. Mefenamic acid and Pau d'arco have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pau d'arco contains naphthoquinones with possible anticoagulant activity, giving a theoretical bleeding risk with NSAIDs. No documented clinical cases confirm this.
How serious is the interaction between Mefenamic acid and Pau d'arco?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report bleeding or bruising and avoid the combination in those at high bleeding risk.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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