Drug interactions
Mefenamic acid + Reishi
Severity: Minor
Mefenamic acid and Reishi: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has been reported to have antiplatelet activity in laboratory studies, so combining it with an NSAID could theoretically increase bleeding tendency. Clinical evidence is scant.
What this interaction means in plain words
Mefenamic acid and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive inhibition of platelet aggregation; not well established in humans.
What to do
Ask patients about reishi use and advise watching for bruising or bleeding. Consider stopping reishi if bleeding signs occur or before procedures.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Reishi?
MediHelp rates the interaction as minor. Mefenamic acid and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has been reported to have antiplatelet activity in laboratory studies, so combining it with an NSAID could theoretically increase bleeding tendency. Clinical evidence is scant.
How serious is the interaction between Mefenamic acid and Reishi?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about reishi use and advise watching for bruising or bleeding. Consider stopping reishi if bleeding signs occur or before procedures.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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