Drug interactions
Mefenamic acid + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Mefenamic acid and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause fluid and electrolyte disturbances including hyponatremia, and NSAIDs may promote water retention and reduce renal perfusion. Concurrent use raises the risk of electrolyte imbalance and kidney injury.
What this interaction means in plain words
Mefenamic acid and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-related fluid and electrolyte shifts combined with NSAID-mediated prostaglandin inhibition affecting renal blood flow and water excretion.
What to do
Avoid the NSAID during bowel preparation when feasible and ensure adequate hydration. Monitor sodium, potassium and creatinine in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Mefenamic acid and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause fluid and electrolyte disturbances including hyponatremia, and NSAIDs may promote water retention and reduce renal perfusion. Concurrent use raises the risk of electrolyte imbalance and kidney injury.
How serious is the interaction between Mefenamic acid and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID during bowel preparation when feasible and ensure adequate hydration. Monitor sodium, potassium and creatinine in high-risk patients.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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