Drug interactions
Mefenamic acid + Telmisartan
Severity: Moderate
Mefenamic acid and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the blood pressure lowering effect of angiotensin receptor blockers and, in combination, raise the risk of acute kidney injury and hyperkalemia. Risk is greatest in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Mefenamic acid and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAIDs block vasodilatory renal prostaglandins, reducing glomerular perfusion while the ARB removes efferent arteriolar tone, impairing filtration and potassium excretion.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Avoid prolonged use and prefer a non-NSAID analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Mefenamic acid with Telmisartan?
MediHelp rates the interaction as moderate. Mefenamic acid and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the blood pressure lowering effect of angiotensin receptor blockers and, in combination, raise the risk of acute kidney injury and hyperkalemia. Risk is greatest in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Mefenamic acid and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Avoid prolonged use and prefer a non-NSAID analgesic in high-risk patients.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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