Drug interactions
Mefenamic acid + Tenofovir df
Severity: Moderate
Mefenamic acid and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can reduce renal perfusion. Combined use may raise tenofovir exposure and the risk of acute kidney injury or tubular toxicity.
What this interaction means in plain words
Mefenamic acid and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related renal hemodynamic impairment and shared renal elimination pathways increase tenofovir exposure and nephrotoxic risk.
What to do
Prefer paracetamol or another non-NSAID analgesic; if an NSAID is needed, use the shortest course and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Tenofovir df?
MediHelp rates the interaction as moderate. Mefenamic acid and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can reduce renal perfusion. Combined use may raise tenofovir exposure and the risk of acute kidney injury or tubular toxicity.
How serious is the interaction between Mefenamic acid and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic; if an NSAID is needed, use the shortest course and monitor serum creatinine and phosphate.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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