Drug interactions
Mefenamic acid + Triamcinolone acetonide injectable
Severity: Moderate
Mefenamic acid and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. A single injection of triamcinolone has lower risk than sustained systemic steroids but systemic exposure can still occur.
What this interaction means in plain words
Mefenamic acid and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects on mucosal healing.
What to do
Limit the duration of NSAID use and consider gastroprotection with a proton pump inhibitor in patients at risk. Advise patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Mefenamic acid and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. A single injection of triamcinolone has lower risk than sustained systemic steroids but systemic exposure can still occur.
How serious is the interaction between Mefenamic acid and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of NSAID use and consider gastroprotection with a proton pump inhibitor in patients at risk. Advise patients to report black stools or abdominal pain.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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