Drug interactions
Mefenamic acid + Vorapaxar
Severity: Major
Mefenamic acid and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a potent antiplatelet agent and NSAIDs add platelet inhibition and gastric mucosal injury. The combination increases bleeding risk, especially gastrointestinal bleeding.
What this interaction means in plain words
Mefenamic acid and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effects (PAR-1 antagonism plus COX inhibition) with NSAID-related mucosal damage.
What to do
Avoid regular NSAID use with vorapaxar where possible, using paracetamol instead. If necessary, use the shortest course with gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Vorapaxar?
MediHelp rates the interaction as major. Mefenamic acid and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a potent antiplatelet agent and NSAIDs add platelet inhibition and gastric mucosal injury. The combination increases bleeding risk, especially gastrointestinal bleeding.
How serious is the interaction between Mefenamic acid and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with vorapaxar where possible, using paracetamol instead. If necessary, use the shortest course with gastroprotection and monitor for bleeding.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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