Drug interactions
Mefloquine + Midazolam intranasal
Severity: Moderate
Mefloquine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may modestly raise midazolam exposure by CYP3A4 inhibition. This may prolong sedation and increase respiratory depression risk.
What this interaction means in plain words
Mefloquine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces midazolam metabolism.
What to do
Monitor sedation and respiratory status after dosing. Allow longer observation before the patient is considered recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Mefloquine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may modestly raise midazolam exposure by CYP3A4 inhibition. This may prolong sedation and increase respiratory depression risk.
How serious is the interaction between Mefloquine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after dosing. Allow longer observation before the patient is considered recovered.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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