Drug interactions
Mefloquine + Olanzapine
Severity: Moderate
Mefloquine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a relatively small QT effect, but mefloquine also prolongs QT and both can affect the central nervous system. The combination may modestly increase the risk of arrhythmia and neuropsychiatric adverse effects.
What this interaction means in plain words
Mefloquine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization and overlapping CNS effects.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities; monitor for palpitations, syncope and worsening psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Mefloquine with Olanzapine?
MediHelp rates the interaction as moderate. Mefloquine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a relatively small QT effect, but mefloquine also prolongs QT and both can affect the central nervous system. The combination may modestly increase the risk of arrhythmia and neuropsychiatric adverse effects.
How serious is the interaction between Mefloquine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities; monitor for palpitations, syncope and worsening psychiatric symptoms.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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