Drug interactions
Mefloquine + Olodaterol inhaled
Severity: Moderate
Mefloquine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can prolong the QT interval, and beta2 agonists such as olodaterol may add to cardiac effects including tachycardia, hypokalemia and QT prolongation. Together they may raise the risk of ventricular arrhythmias, particularly in patients with heart disease or electrolyte disturbances.
What this interaction means in plain words
Mefloquine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta2-mediated cardiovascular stimulation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations and rhythm changes, and avoid the combination in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Mefloquine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can prolong the QT interval, and beta2 agonists such as olodaterol may add to cardiac effects including tachycardia, hypokalemia and QT prolongation. Together they may raise the risk of ventricular arrhythmias, particularly in patients with heart disease or electrolyte disturbances.
How serious is the interaction between Mefloquine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations and rhythm changes, and avoid the combination in patients with known QT prolongation.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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