Drug interactions
Mefloquine + Pindolol
Severity: Moderate
Mefloquine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia and conduction disturbances, and pindolol, a beta-blocker, can add to these effects. The combination may result in symptomatic bradycardia or AV block.
What this interaction means in plain words
Mefloquine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and conduction effects; a pharmacokinetic interaction is not well established.
What to do
Monitor pulse and ECG at the start of co-therapy and after dose changes. Choose another antimalarial if significant bradycardia or conduction delay develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Pindolol?
MediHelp rates the interaction as moderate. Mefloquine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause bradycardia and conduction disturbances, and pindolol, a beta-blocker, can add to these effects. The combination may result in symptomatic bradycardia or AV block.
How serious is the interaction between Mefloquine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and ECG at the start of co-therapy and after dose changes. Choose another antimalarial if significant bradycardia or conduction delay develops.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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