Drug interactions
Mefloquine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Mefloquine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol may have a small QT-prolonging effect and adrenergic stimulation can add to arrhythmia risk. With mefloquine, the increase in risk is likely modest at inhaled doses.
What this interaction means in plain words
Mefloquine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta-agonist cardiac effects.
What to do
Monitor for palpitations and arrhythmia, and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Mefloquine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol may have a small QT-prolonging effect and adrenergic stimulation can add to arrhythmia risk. With mefloquine, the increase in risk is likely modest at inhaled doses.
How serious is the interaction between Mefloquine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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