Drug interactions
Mefloquine + Vincristine liposomal
Severity: Moderate
Mefloquine and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine inhibits P-glycoprotein and could increase vincristine exposure, potentially worsening neurotoxicity. Clinical evidence is limited and the liposomal form has altered distribution.
What this interaction means in plain words
Mefloquine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of P-gp efflux of vincristine by mefloquine.
What to do
Monitor for peripheral neuropathy, constipation and other vincristine toxicity. Consider an alternative antimalarial if neurotoxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Vincristine liposomal?
MediHelp rates the interaction as moderate. Mefloquine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine inhibits P-glycoprotein and could increase vincristine exposure, potentially worsening neurotoxicity. Clinical evidence is limited and the liposomal form has altered distribution.
How serious is the interaction between Mefloquine and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and other vincristine toxicity. Consider an alternative antimalarial if neurotoxicity appears.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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