Drug interactions
Meloxicam + Milnacipran
Severity: Moderate
Meloxicam and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining meloxicam with milnacipran raises the risk of bleeding, particularly upper gastrointestinal bleeding.
What this interaction means in plain words
Meloxicam and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Serotonin-norepinephrine reuptake inhibition depletes platelet serotonin and impairs aggregation, adding to NSAID antiplatelet and mucosal-damaging effects.
What to do
Monitor for gastrointestinal bleeding signs and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Meloxicam with Milnacipran?
MediHelp rates the interaction as moderate. Meloxicam and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining meloxicam with milnacipran raises the risk of bleeding, particularly upper gastrointestinal bleeding.
How serious is the interaction between Meloxicam and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding signs and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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