Drug interactions
Meloxicam + Probenecid
Severity: Moderate
Meloxicam and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can increase meloxicam concentrations, raising the risk of NSAID adverse effects such as gastrointestinal and renal toxicity.
What this interaction means in plain words
Meloxicam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular organic anion transport, reducing meloxicam renal clearance.
What to do
Use the lowest effective meloxicam dose and monitor for gastrointestinal and renal adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Meloxicam with Probenecid?
MediHelp rates the interaction as moderate. Meloxicam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can increase meloxicam concentrations, raising the risk of NSAID adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Meloxicam and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose and monitor for gastrointestinal and renal adverse effects.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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