Drug interactions
Meloxicam + Sertraline
Severity: Moderate
Meloxicam and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking meloxicam with sertraline increases the risk of bleeding, particularly in the upper gastrointestinal tract.
What this interaction means in plain words
Meloxicam and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRIs reduce platelet serotonin and impair aggregation, adding to NSAID antiplatelet effects and mucosal injury.
What to do
Monitor for bleeding signs and consider a proton pump inhibitor in high-risk patients; use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Meloxicam with Sertraline?
MediHelp rates the interaction as moderate. Meloxicam and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking meloxicam with sertraline increases the risk of bleeding, particularly in the upper gastrointestinal tract.
How serious is the interaction between Meloxicam and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider a proton pump inhibitor in high-risk patients; use the lowest NSAID dose for the shortest time.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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