Drug interactions
Meloxicam + Ticagrelor
Severity: Moderate
Meloxicam and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with the P2Y12 inhibitor ticagrelor raises the risk of bleeding, particularly in the gastrointestinal tract. NSAIDs injure the gastric mucosa and impair platelet function, which adds to ticagrelor's antiplatelet effect.
What this interaction means in plain words
Meloxicam and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect on platelet function plus NSAID-related gastric mucosal injury.
What to do
Avoid routine NSAID use in patients on ticagrelor where possible, preferring paracetamol for analgesia. If an NSAID is needed, use the lowest dose for the shortest time, consider gastroprotection with a proton pump inhibitor and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Meloxicam with Ticagrelor?
MediHelp rates the interaction as moderate. Meloxicam and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with the P2Y12 inhibitor ticagrelor raises the risk of bleeding, particularly in the gastrointestinal tract. NSAIDs injure the gastric mucosa and impair platelet function, which adds to ticagrelor's antiplatelet effect.
How serious is the interaction between Meloxicam and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine NSAID use in patients on ticagrelor where possible, preferring paracetamol for analgesia. If an NSAID is needed, use the lowest dose for the shortest time, consider gastroprotection with a proton pump inhibitor and monitor for bleeding.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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