Drug interactions
Meloxicam + Tolazamide
Severity: Minor
Meloxicam and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is inconsistent and mainly reported with older NSAIDs, so the risk with meloxicam is likely small.
What this interaction means in plain words
Meloxicam and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meloxicam belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding or reduced renal clearance of the sulfonylurea; mechanism not firmly established.
What to do
Counsel the patient on hypoglycemia symptoms and check blood glucose more often when starting or stopping meloxicam. Reduce the tolazamide dose if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meloxicam and Tolazamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Meloxicam with Tolazamide?
MediHelp rates the interaction as minor. Meloxicam and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is inconsistent and mainly reported with older NSAIDs, so the risk with meloxicam is likely small.
How serious is the interaction between Meloxicam and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on hypoglycemia symptoms and check blood glucose more often when starting or stopping meloxicam. Reduce the tolazamide dose if glucose falls.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
