Drug interactions
Meloxicam + Voclosporin
Severity: Major
Meloxicam and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can reduce glomerular filtration, voclosporin by afferent arteriolar vasoconstriction as a calcineurin inhibitor and meloxicam by blocking vasodilatory prostaglandins. Together they raise the risk of acute kidney injury, particularly in lupus nephritis patients with already reduced renal function.
What this interaction means in plain words
Meloxicam and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meloxicam belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin-inhibitor vasoconstriction and NSAID prostaglandin inhibition.
What to do
Avoid NSAIDs where possible and use an alternative analgesic. If unavoidable, monitor eGFR and serum creatinine closely and review the voclosporin dose if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Meloxicam with Voclosporin?
MediHelp rates the interaction as major. Meloxicam and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can reduce glomerular filtration, voclosporin by afferent arteriolar vasoconstriction as a calcineurin inhibitor and meloxicam by blocking vasodilatory prostaglandins. Together they raise the risk of acute kidney injury, particularly in lupus nephritis patients with already reduced renal function.
How serious is the interaction between Meloxicam and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use an alternative analgesic. If unavoidable, monitor eGFR and serum creatinine closely and review the voclosporin dose if renal function declines.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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