Drug interactions
Meloxicam + Zafirlukast
Severity: Minor
Meloxicam and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam is cleared mainly by CYP2C9, which zafirlukast inhibits in vitro. Any increase in meloxicam exposure is likely small.
What this interaction means in plain words
Meloxicam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meloxicam belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast may inhibit CYP2C9-mediated metabolism of meloxicam.
What to do
No adjustment is needed. Use the lowest effective meloxicam dose and watch for GI or renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Zafirlukast?
MediHelp rates the interaction as minor. Meloxicam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meloxicam is cleared mainly by CYP2C9, which zafirlukast inhibits in vitro. Any increase in meloxicam exposure is likely small.
How serious is the interaction between Meloxicam and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Use the lowest effective meloxicam dose and watch for GI or renal adverse effects.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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