Drug interactions
Melphalan + Voclosporin
Severity: Moderate
Melphalan and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause dose-related nephrotoxicity, and melphalan is renally cleared with dose reduction needed in renal impairment. Reduced renal function may raise melphalan exposure and myelosuppression, while the combination adds immunosuppression.
What this interaction means in plain words
Melphalan and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melphalan belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor nephrotoxicity may reduce melphalan clearance, with additive immunosuppression.
What to do
Monitor serum creatinine/eGFR and blood counts closely, and adjust melphalan dose for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Melphalan with Voclosporin?
MediHelp rates the interaction as moderate. Melphalan and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause dose-related nephrotoxicity, and melphalan is renally cleared with dose reduction needed in renal impairment. Reduced renal function may raise melphalan exposure and myelosuppression, while the combination adds immunosuppression.
How serious is the interaction between Melphalan and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine/eGFR and blood counts closely, and adjust melphalan dose for renal function.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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