Drug interactions
Memantine + Metformin
Severity: Minor
Memantine and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both memantine and metformin are cationic drugs eliminated by renal tubular secretion, so they may compete for transport and slightly alter each other's clearance. No clinically important effect has been established at usual doses.
What this interaction means in plain words
Memantine and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) may reduce clearance of either drug.
What to do
No dose change is generally needed. Monitor glycemic control and renal function, particularly in older patients with reduced kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Metformin
Frequently asked questions
Can I take Memantine with Metformin?
MediHelp rates the interaction as minor. Memantine and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both memantine and metformin are cationic drugs eliminated by renal tubular secretion, so they may compete for transport and slightly alter each other's clearance. No clinically important effect has been established at usual doses.
How serious is the interaction between Memantine and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor glycemic control and renal function, particularly in older patients with reduced kidney function.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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