Drug interactions
Memantine + Methyclothiazide
Severity: Minor
Memantine and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is renally eliminated in part by tubular secretion, and thiazides such as hydrochlorothiazide have been reported to reduce memantine exposure slightly. Methyclothiazide is expected to have no important effect, and any change would be small.
What this interaction means in plain words
Memantine and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion, though the effect is not well established for this thiazide.
What to do
No action is needed beyond routine clinical monitoring of response to memantine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Memantine and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Methyclothiazide?
MediHelp rates the interaction as minor. Memantine and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is renally eliminated in part by tubular secretion, and thiazides such as hydrochlorothiazide have been reported to reduce memantine exposure slightly. Methyclothiazide is expected to have no important effect, and any change would be small.
How serious is the interaction between Memantine and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine clinical monitoring of response to memantine.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
