Drug interactions
Memantine + Sulfamethoxazole
Severity: Minor
Memantine and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole may compete with memantine for renal tubular handling, though the effect is probably small. Memantine accumulation would be mainly a concern in renal impairment.
What this interaction means in plain words
Memantine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion transporters.
What to do
No routine adjustment is needed; monitor for dizziness or confusion in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Memantine and Sulfamethoxazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Sulfamethoxazole?
MediHelp rates the interaction as minor. Memantine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole may compete with memantine for renal tubular handling, though the effect is probably small. Memantine accumulation would be mainly a concern in renal impairment.
How serious is the interaction between Memantine and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dizziness or confusion in patients with reduced renal function.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
