Drug interactions
Memantine + Tenofovir df
Severity: Moderate
Memantine and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal tubular handling, and tenofovir may compete with memantine for secretion, potentially raising levels of either. Tenofovir can also impair renal function, which further reduces memantine clearance.
What this interaction means in plain words
Memantine and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and possible tenofovir-related reduction in renal function.
What to do
Monitor renal function and memantine adverse effects, and reduce the memantine dose if creatinine clearance falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Tenofovir df?
MediHelp rates the interaction as moderate. Memantine and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs undergo renal tubular handling, and tenofovir may compete with memantine for secretion, potentially raising levels of either. Tenofovir can also impair renal function, which further reduces memantine clearance.
How serious is the interaction between Memantine and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and memantine adverse effects, and reduce the memantine dose if creatinine clearance falls.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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