Drug interactions
Memantine + Tenofovir disoproxil
Severity: Minor
Memantine and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated mainly by the kidney with tubular secretion, so competition with tenofovir could raise concentrations of either drug. Clinical evidence is limited, but memantine accumulation may cause dizziness, confusion and agitation.
What this interaction means in plain words
Memantine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion via cationic transporters.
What to do
No empirical adjustment is needed. Monitor for memantine adverse effects and review doses if renal function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Memantine with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Memantine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated mainly by the kidney with tubular secretion, so competition with tenofovir could raise concentrations of either drug. Clinical evidence is limited, but memantine accumulation may cause dizziness, confusion and agitation.
How serious is the interaction between Memantine and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Monitor for memantine adverse effects and review doses if renal function is reduced.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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