Drug interactions
Memantine-donepezil + Nifedipine
Severity: Minor
Memantine-donepezil and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a CYP3A4 substrate with weak inhibitory activity, so a meaningful rise in donepezil is unlikely. Donepezil's vagotonic effect may also add to bradycardia or hypotension in susceptible patients.
What this interaction means in plain words
Memantine-donepezil and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 competition; pharmacodynamic additive effects on heart rate and blood pressure are also possible.
What to do
No dose adjustment; monitor heart rate and blood pressure when the combination is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Memantine-donepezil with Nifedipine?
MediHelp rates the interaction as minor. Memantine-donepezil and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a CYP3A4 substrate with weak inhibitory activity, so a meaningful rise in donepezil is unlikely. Donepezil's vagotonic effect may also add to bradycardia or hypotension in susceptible patients.
How serious is the interaction between Memantine-donepezil and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment; monitor heart rate and blood pressure when the combination is started.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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