Drug interactions
Memantine-donepezil + Pasireotide
Severity: Moderate
Memantine-donepezil and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide and donepezil can each prolong the QT interval, and pasireotide also causes bradycardia, which donepezil may worsen. Together they raise the risk of arrhythmia.
What this interaction means in plain words
Memantine-donepezil and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with additive bradycardia from vagotonic donepezil and pasireotide.
What to do
Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Monitor heart rate and watch for syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Memantine-donepezil with Pasireotide?
MediHelp rates the interaction as moderate. Memantine-donepezil and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide and donepezil can each prolong the QT interval, and pasireotide also causes bradycardia, which donepezil may worsen. Together they raise the risk of arrhythmia.
How serious is the interaction between Memantine-donepezil and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Monitor heart rate and watch for syncope.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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