Drug interactions
Memantine-donepezil + Salmeterol
Severity: Minor
Memantine-donepezil and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can cause tachycardia, hypokalemia and QT prolongation at higher exposures, and donepezil can prolong the QT interval. Together they may add modestly to arrhythmia risk.
What this interaction means in plain words
Memantine-donepezil and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT effects, with beta-agonist-related hypokalemia as a contributing factor.
What to do
Use usual inhaled doses and avoid exceeding recommended limits. Check ECG and potassium in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Memantine-donepezil with Salmeterol?
MediHelp rates the interaction as minor. Memantine-donepezil and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol can cause tachycardia, hypokalemia and QT prolongation at higher exposures, and donepezil can prolong the QT interval. Together they may add modestly to arrhythmia risk.
How serious is the interaction between Memantine-donepezil and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use usual inhaled doses and avoid exceeding recommended limits. Check ECG and potassium in patients with cardiac disease.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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