Drug interactions
Memantine-donepezil + Scopolamine
Severity: Moderate
Memantine-donepezil and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is an antimuscarinic that directly opposes donepezil's cholinergic effect. It may also cause confusion, sedation and delirium in patients with dementia.
What this interaction means in plain words
Memantine-donepezil and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid scopolamine in patients with dementia where possible and choose a non-anticholinergic antiemetic. If used, monitor cognition and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Scopolamine
Frequently asked questions
Can I take Memantine-donepezil with Scopolamine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is an antimuscarinic that directly opposes donepezil's cholinergic effect. It may also cause confusion, sedation and delirium in patients with dementia.
How serious is the interaction between Memantine-donepezil and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid scopolamine in patients with dementia where possible and choose a non-anticholinergic antiemetic. If used, monitor cognition and sedation.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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