Drug interactions
Memantine-donepezil + Sorafenib
Severity: Moderate
Memantine-donepezil and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and donepezil has also been linked to QT prolongation and torsades de pointes. Combined use may add to the risk of serious ventricular arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Memantine-donepezil and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes, correct potassium and magnesium abnormalities, and repeat the ECG periodically during sorafenib therapy. Reassess donepezil if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Memantine-donepezil with Sorafenib?
MediHelp rates the interaction as moderate. Memantine-donepezil and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and donepezil has also been linked to QT prolongation and torsades de pointes. Combined use may add to the risk of serious ventricular arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Memantine-donepezil and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correct potassium and magnesium abnormalities, and repeat the ECG periodically during sorafenib therapy. Reassess donepezil if QTc becomes markedly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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