Drug interactions
Memantine-donepezil + Telavancin
Severity: Moderate
Memantine-donepezil and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telavancin and donepezil can each lengthen the QT interval, so together they may raise the risk of serious ventricular arrhythmias. The risk is greater with structural heart disease or electrolyte disturbances.
What this interaction means in plain words
Memantine-donepezil and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG for QTc changes during telavancin therapy and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with baseline QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Memantine-donepezil with Telavancin?
MediHelp rates the interaction as moderate. Memantine-donepezil and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telavancin and donepezil can each lengthen the QT interval, so together they may raise the risk of serious ventricular arrhythmias. The risk is greater with structural heart disease or electrolyte disturbances.
How serious is the interaction between Memantine-donepezil and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QTc changes during telavancin therapy and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with baseline QT prolongation.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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