Drug interactions
Memantine-donepezil + Triamterene
Severity: Minor
Memantine-donepezil and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine and triamterene are both eliminated by renal tubular cationic secretion, so competition may raise levels of either drug. The clinical effect is usually small, though triamterene accumulation can contribute to hyperkalemia in renal impairment.
What this interaction means in plain words
Memantine-donepezil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular cationic transport may reduce triamterene and memantine clearance.
What to do
No routine adjustment; monitor serum potassium and renal function, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Memantine-donepezil with Triamterene?
MediHelp rates the interaction as minor. Memantine-donepezil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine and triamterene are both eliminated by renal tubular cationic secretion, so competition may raise levels of either drug. The clinical effect is usually small, though triamterene accumulation can contribute to hyperkalemia in renal impairment.
How serious is the interaction between Memantine-donepezil and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor serum potassium and renal function, particularly in older patients.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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